确定活性成分的质量在止痛药采用气相

疼痛是提醒人类当一些组件的有用功能的生理系统出现的问题。刺激的疼痛是不容易定义也不容易去除,因此有必要治疗疼痛的症状。因此,许多制药公司已经涉足制造业业务的非处方药(OTC),这导致了生产的镇痛药,达到消费者与不同的品牌名称。本研究试图确定的质量对乙酰氨基酚(4 ' -hydroxyacetanilide),阿司匹林(乙酰水杨酸)和咖啡因(3 7-Dihydro-1 3 7-trimethyl-1-H-purine-2 6-dione)活性成分在不同镇痛药物目前在肯尼亚。9止痛药(扑热息痛、行动、hedex maramoja。P500, P5500、elymol neldol和APC平板电脑)被随机购买从不同的商店在内罗毕,肯尼亚和采取乔莫•肯雅塔大学农业和技术(JKUAT)实验室进行分析。提取了使用二氯甲烷(DCM)和活性成分的提取质量分析气相色谱分析-质谱法(gc - ms)。GC - Ms分析使用8 - - -系列执行GC系统Trio-01女士在电子电离检测器(EI)模式。与毛细管柱分离实现TFX-5 (30 mx0.25mm我。0.25 D,µm电影)。结果表明,对乙酰氨基酚含量扑热息痛可比Neladol和Elymol(455 - 560毫克/片),而hedex至少(24毫克/片)。 These values agreed well with the value on the label on the blistered pack. The highest amount of asprin was found in maramoja (937mg/tablet) followed by hedex (790mg/tablet). Panadol, Elymol and Neladol asprin contents were below detectable limits. Maramoja (93mg/tablet) had high amounts of caffeine which was not significant to that of Action 50mg/tablet). Panadol (0.1mg/tablet) had the lowest caffeine content. The outcome of this study suggests the possible availability of counterfeit drugs in the market. The brand mostly affected for analysis of acetaminophen was found in panadol, action, P500, P5500, elymol and neladol.
关键词。止痛药,对乙酰氨基酚、阿司匹林、咖啡因、气相色谱-光谱法