Latest Articles

Team develops novel strategy combining MALDI-IMS and spatially-resolved top-down proteomics to investigate differences in protein expression at the cellular level, in brain tissue.

The metabolome is exquisitely sensitive to our physiology, sitting at the interface of our genome and environment. Developing handheld devices that enable people to monitor themselves for changes in their metabolites that can predict future disease will empower them to take charge of their own healthcare, transforming medicine.

Capillary electrophoresis-mass spectrometry (CE-MS) has remained in the shadows for decades. However, this powerful separation technique is now enjoying a renaissance, with academic and industrial scientists keen to exploit its key advantages. We spoke to some of its most ardent fans to explore a variety of the latest research and clinical applications.

Researchers have worked out the structure of protein progenitor molecules that existed billions of years ago, which may have modern-day uses.

In this article, we provide practical guidance for the application of differential scanning calorimetry (DSC), a core technique for studying the stability and higher order structure (HOS) of proteins. We explain how DSC works, and highlight good practice for ensuring optimal data quality. The interpretation and value of the resulting data is also discussed.

We spoke to Darlene to learn about her reasons for studying science, how she transitioned away from the lab and some of her proudest achievements at Agilent.

It has long been known that the fats we consume in our diet can have an impact on our health. However, their implications on cell differentiation has not previously been understood. We spoke to Professor Ilya Levental about his group's exciting work in this field, the role of lipidomics and how this may affect the future of healthcare.

Mass spectrometry has evolved as a prevailing technique for both the characterization of biotherapeutics and identification of protein variants and post-translational modifications.

Medicine has been moving away from a "one-size-fits-all" approach towards predictive, preventive and treatment strategies tailored to the individual - precision medicine. Quantitative proteomics is playing an important part in this process but there are still some areas in which improvements must be seen before assays are likely to be routinely available to clinicians and patients.

Prof. Giorgio Carta provides us with extraordinary insight into the current state of play, factors to consider when 'scaling up’ separation processes, and general challenges and developments when applying chromatographic techniques to bioprocesses.