可溶性CD14-SUBTYPE PRESEPSIN,一个可能的新生物标志物在败血症的病人的血浆从儿科部门增加。

CD14存在于巨噬细胞、单核细胞和粒细胞细胞膜。其可溶性部分命名presepsin存在于血液与感染,由于微生物吞噬作用。血清浓度的增加presepsin报告严重的细菌性败血症患者在成人中,然而,儿童所知甚少。我们进行了一项研究儿科患者的血浆presepsin浓度。六十一名受试者承认我们医院登记。控制,六无热的,non-septic孩子承认对常规心导管检查对先天性心脏病被录取。血被撤回。一起presepsin化验血培养,白细胞计数、血清c反应蛋白和原降钙素是化验。Presepsin浓度范围195 - 866 pg / ml患者血培养是积极的(n = 5)。另一方面,患者血培养阴性(n = 34)仍在低水平(p = 0.050)。 Control subjects (n=6) showed significantly low concentration compared to blood culture positive children (p=0.019). Since presepsin has been reported to be an indicator of prognosis in adult patients with severe sepsis it could also be applied also to pediatric patients. Because number of subjects is limited, more study is required to confirm the result.