Spatially Encoded Pathways for Immune Tolerance in Human Health and Disease

Normative pathways for immune tolerance can be hijacked in disease, such as in metastatic cancer progression and in tuberculosis (TB). To understand the network of cells and tissues behind immune tolerance, spatial transcriptomics combined with MALDI mass spectrometry can be employed to map the distribution of transcripts, lipids and glycans. These insights can be used to discover regulatory pathways that can be targeted for diagnostic and therapeutic purposes.

In this webinar, Dr. Angelo will showcase his research into understanding the evolving spatiotemporal network behind how immune tolerance develops in cancer, pregnancy and TB.

Attend this webinar to:

• Learn about mass spectrometry-based spatial biology techniques
• Understand tissue structure-function relationships in disease
• Hear about how normative pathways for immune tolerance are hijacked in disease