鉴定代谢产物在正常卵巢及其转换原发性和转移性卵巢癌

文摘

表征人类卵巢和识别的代谢物的代谢交替变化,配合原发性卵巢上皮癌(转换端)和转移性肿瘤引起的原发性卵巢癌(moc)是通过使用三个分析平台:气相色谱质谱(GC / MS)和液相色谱串联质谱(LC / MS / MS)使用缓冲系统和仪器设置目录积极或消极的离子。人类卵巢癌代谢组是364年发现含有生化药剂和转换引起的卵巢能量利用率的变化,改变与糖酵解相关的代谢和脂肪所β-oxidation的肉碱(在转换端1.79折,p < 0.001;在商务部1.88折,p < 0.001), acetylcarnitine(在转换端1.75折,p < 0.001;在商务部2.39折,p < 0.001),和butyrylcarnitine(3.62折,p < 0.0094转换端;7.88折,在商务部p < 0.001)。也有重大的改变在苯丙氨酸分解代谢,增加phenylpyruvate(4.21折;p = 0.0098)和phenyllactate(195.45折;在转换端p < 0.0023)。卵巢癌也显示一个增强氧化应激反应的增加在2-aminobutyrate OC(1.46折,p = 0.0316)和商务部(2.25折,p < 0.001)和天然维生素e的几个亚型。我们还发现小说代谢物在卵巢,特别是N-acetylasparate N-acetyl-aspartyl-glutamate,在卵巢生理的作用还有待确定。 These data enhance our understanding of the diverse biochemistry of the human ovary and demonstrate metabolic alterations upon transformation. Furthermore, metabolites with significant changes between groups provide insight into biochemical consequences of transformation and are candidate biomarkers of ovarian oncogenesis. Validation studies are warranted to determine whether these compounds have clinical utility in the diagnosis or clinical management of ovarian cancer patients.

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